Latt KZ, Honda K, Thiri M, Hitomi Y, Omae Y, Sawai H, Kawai Y, Teraguchi S, Ueno K, Nagasaki M, Mabuchi A, Kaga H, Komatsuda A, Tokunaga K, and Noiri E. Identification of a two-SNP PLA2R1 haplotype and HLA-DRB1 alleles as primary risk associations in idiopathic membranous nephropathy. Sci. Rep. 8(1): e15576, 2018.

Miyagawa T, Khor SS, Toyoda H, Kanbayashi T, Imanishi A, Sagawa Y, Kotorii N, Kotorii T, Ariyoshi Y, Hashizume Y, Ogi K, Hiejima H, Kamei Y, Hida A, Miyamoto M, Ikegami A, Wada Y, Takami M, Higashiyama Y, Fukai R, Kondo H, Fujimura Y, Tamura Y, Taniyama Y, Omata N, Tanaka Y, Moriya S, Furuya H, Kato M, Kawamura Y, Honda Y, Miyashita A, Kojima H, Saji H, Shimada M, Yamasaki M, Kobayashi T, Misawa R, Shigematsu Y, Kuwano R, Sasaki T, Ishigooka J, Wada Y, Tsuruta K, Chiba S, Tanaka F, Yamada N, Okawa M, Kuroda K, Kume K, Hirata K, Uchimura N, Shimizu T, Inoue Y, Mishima K, Honda M, and Tokunaga K. A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia. J. Hum. Genet. 63(12): 1259-1267, 2018.

Aiba Y, Harada K, Ito M, Suematsu T, Aishima S, Hitomi Y, Nishida N, Kawashima M, Takatsuki M, Eguchi S, Shimoda S, Nakamura H, Komori A, Abiru S, Nagaoka S, Migita K, Yatsuhashi H, Tokunaga K,and Nakamura M. Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. Sci. Rep. 8(1): e11808, 2018.

HanB, AkiyamaM, KimKK, OhH, ChoiH, LeeCH, JungS, LeeHS, KimEE, CookS, HarituniansT, YamazakiK, ParkSH, YeBD, McGovern DPB, EsakiM, KawaguchiT, KhorSS, TaylorKD, RotterJI, SuzukiY, MatsuiT, MotoyaS, BangSY, KimTH, MomozawaY, KamataniY, TokunagaK, KuboM, OkadaY, YangSK, and Song K. Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn’s disease in Asians. Hum. Mol. Genet. 27(22): 3901-3910, 2018.

Palittapongarnpim P, Ajawatanawong P, ViratyosinW, Smittipat N, Disratthakit A, Mahasirimongkol S, Yanai H, Yamada N, Nedsuwan S, Imasanguan W, Kantipong P, Chaiyasirinroje B, Wongyai J, Toyo-oka L, Phelan J, Parkhill J, Clark T.G., Hibberd M.L., Ruengchai W, Palittapongarnpim P, Juthayothin T, Tongsima S, and Tokunaga K. Evidence for host-bacterial co-evolution via genome sequence analysis of 480 Thai Mycobacterium tuberculosis lineage 1 isolates. Sci. Rep. 8(1): e11597, 2018.

JiaX, HorinouchiT, HitomiY, ShonoA, KhorSS, OmaeY, KojimaK, KawaiY, NagasakiM, KakuY, OkamotoT, OhwadaY, OhtaK, OkudaY, FujimaruR, HataeK, KumagaiN, SawanoboriE, NakazatoH, OhtsukaY, NakanishiK, ShimaY, TanakaR, AshidaA, KameiK, IshikuraK, NozuK, TokunagaK, and IijimaK. for the Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan.Strong association of HLA-DR/DQ locus with childhood steroid-sensitive nephrotic syndrome in the Japanese population. J. Am. Soc. Nephrol. 29(8): 2189-2199, 2018.

NishidaN, AibaY, HitomiY, KawashimaM, KjimaK, KawaiY, UenoK, NakamuraH, YamashikiN, TanakaT, TamuraS, MoriA, YagiS, SoejimaY, YoshizumiT, TakatsukiM, TanakaA, HaradaK, ShimodaS, KomoriA, EguchiS, MaeharY, UemotoS, KokudoN, NagasakiM, TokunagaK, and Nakamura M. NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population. Sci. Rep. 8(1): e8071, 2018.

SawaiH, NishidaN, KhorSS, HondaM, SugiyamaM, BabaN, YamadaK, SawadaN, TsuganeS, KoikeK, KondoY, YatsuhashiH, NagaokaS, TaketomiA, FukaiM, KurosakiM, IzumiN, KangJH, MurataK, HinoK, NishinaS, MatsumotoA, TanakaE, SakamotoN, OgawaK, YamamotoK, TamoriA, YokosukaO, KandaT, SakaidaI, ItohY, EguchiY, Satoshi OedaS, MochidaS, YuenMF, SetoWK, PoovorawanY, PosuwanN, MizokamiM and Tokunaga K. Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma. Sci. Rep. 8(1): e7958, 2018.

Suvichapanich S, Fukunaga K, Zahroh H, Mushiroda T, Mahasirimongkol S, Toyo-Oka L, Chaikledkaew U, Jittikoon J, Yuliwulandari R, Yanai H, Wattanapokayakit S, and Tokunaga K. NAT2 ultra-slow acetylator and risk of anti-tuberculosis drug-induced liver injury: a genotype-based meta-analysis. Pharmacogenet. Genomics 28(7): 167-176, 2018.

Im C, Sapkota Y, Moon W, Kawashima M, Nakamura M, Tokunaga K, and Yasui Y. Genome-wide haplotype association analysis of primary biliary cholangitis risk in Japanese. Sci. Rep. 8(1): e7806, 2018.

Nishida N*, SugiyamaM*, SawaiH*(equal contribution), NishinaS, SakaiA, OhashiJ, KhorSS, KakisakaK, TsuchiuraT, HinoK, SumazakiR, TakikawaY, MurataK, KandaT, YokosukaO, TokunagaK, and MizokamiM. Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine. Hepatol. 68(3): 848-858, 2018.

Shimada M, Miyagawa T, Toyoda H, Tokunaga K, and Honda M. Epigenome-wide association study of DNA methylation in narcolepsy: an integrated genetic and epigenetic approach. Sleep 41(4): zsy019, 2018.

Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S. Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl. Psychiatry 8(1): e41, 2018.

Khor SS, MorinoR, NakazonoK, KamitsujiS, AkitaM, KawajiriM, YamasakiT, KamiA, HoshiY, TadaA, IshikawaK, HineM, KobayashiM, KurumeN, KamataniN, TokunagaK, and JohnsonTA. Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region. Sci. Rep. 8(1): e1069, 2018.

Suzuki A, Kawano S, Mituyama T, Suyama M, Kanai Y, Shirahige K, Sasaki H, Tokunaga K, Tsuchihara K, Sugano S, Nakai K, and Suzuki Y. DBTSS/DBKERO for integrated analysis of transcriptional regulation. Nucleic Acids Research 46(D1): D229-D238, 2018.

Shimada M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, and Sasaki T. An epigenome-wide methylation study of healthy individuals with or without depressive symptoms. J. Hum. Genet. 63(3): 319-326, 2018.

Ueta M, Hamuro J, Nishigaki H, Nakamura N, Shinomiya K, Mizushima K, Hitomi Y, Tamagawa-Mineoka R, Yokoi N, Naito Y, Tokunaga K, Katoh N, Sotozono C, Kinoshita S. Mucocutaneous inflammation in the Ikaros Family Zinc Finger 1-keratin 5-specific transgenic mice. Allergy 73(2): 395-404, 2018.