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徳永 勝士

理学博士(東京大学理学系研究科、昭和59年)

出身地:愛媛県

  • 1) さまざまな多因子疾患および薬剤・治療応答性に関わる遺伝要因のゲノム全域探索
  • 2) HLA遺伝子群およびゲノム全域の多型解析によるアジア系諸集団の多様性と医学的意義
  • 3) ナショナルセンター・バイオバンクネットワークの整備、利活用と発展

学歴

  • 東京大学理学部生物学科(人類学教室)卒業

    昭和52年
  • 東京大学理学系大学院修士課程修了

    昭和54年
  • 東京大学理学系大学院博士課程単位取得のうえ退学

    昭和57年

職歴

  • 日本学術振興会奨励研究員

    昭和57年
  • 東京大学理学部人類学教室 助手
    (昭和62年から63年までオーストラリア・パース Royal Perth Hospital, Dept. of Clinical ImmunologyにてSenior Research Fellowとして研究)

    昭和58年
  • 東京大学医学部附属病院輸血部 助手

    平成元年
  • 日本赤十字中央血液センター研究部 課長

    平成4年
  • 東京大学大学院医学系研究科(国際保健学専攻)人類遺伝学分野 教授

    平成7年
  • 国立国際医療研究センター ゲノム医科学プロジェクト戸山プロジェクト長
    ナショナルセンターバイオバンクネットワーク・中央バイオバンク長(兼任)

    平成31年

所属学会

日本組織適合性学会(理事長)、日本人類遺伝学会(理事)、日本人類学会(評議員)、日本分子生物学会、国際HLA・免疫遺伝学会議カウンシルメンバー、米国人類遺伝学会、ヨーロッパ人類遺伝学会、米国組織適合性・免疫遺伝学会、ヨーロッパ免疫遺伝学会 など

学術誌委員

Human Genome Variation: Editor-in-Chief

Journal of Human Genetics: Advisory Editor

HLA (Tissue Antigens): Advisory Editor

International Journal of Immunogenetics: Advisory Board

Anthropological Science: Editorial Board など

代表的な発表論文

Tokunaga K, Sauerecker G, Kay P, Christiansen F, Anand R, and Dawkins RL: Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis. J. Exp. Med. 168: 933-940, 1988.
Watanabe Y, Tokunaga K, Matsuki K, Takeuchi F, Matsuta K, Maeda H, Omoto K, and Juji T: Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility. J. Exp. Med. 169: 2263-2268, 1989.
Uchigata Y, Kuwata S, Tokunaga K, Eguchi Y, Takayama-Hasumi S, Miyamoto M, Omori Y, Juji T, and Hirata Y: Strong association of insulin autoimmune syndrome with HLA-DR4. Lancet 339: 393-394, 1992.
Wang L, Juji T, Tokunaga K, Takahashi K, Kuwata S, Uchida S, Tadokoro K, and Takai K: Polymorphic microsatellite markers for the diagnosis of graft-versus-host disease. N. Engl. J. Med. 330: 398-401, 1994.
Tokunaga K, Ishikawa Y, Ogawa A, Wang H, Mitsunaga S, Moriyama S, Lin L, Bannai M, Watanabe Y, Kashiwase K, Tanaka H, Akaza T, Tadokoro K, and Juji T: Sequence-based association analysis of HLA class I and II alleles in Japanese supports conservation of common haplotypes. Immunogenet. 46: 199-205, 1997.
Kobayashi K, Nakahori Y, Miyake M, Matsumura K, Kondo-lida E, Momura Y, Segawa M, Yoshioka M, Saito K, Osawa M, Hamano K, Sakakibara Y, Nonaka I, Nakagome Y, Kanazawa I, Nakamura Y, Tokunaga K, and Toda T: An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature 394: 388-392, 1998.
Tsuchiya N, Ohashi J, and Tokunaga K: Variations in immune response genes and their associations with multifactorial immune disorders. Immunol. Rev. 190: 169-181, 2002.
Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, and Tokunaga K: CD36 polymorphism is associated with protection from cerebral malaria. Am. J. Hum. Genet. 72: 364-374, 2003.
Kuroki K, Tsuchiya N, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukazawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, and Tokunaga K: Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum. Mol. Genet. 14: 2469-2480, 2005.
Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko V, Alipov G, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano C, Ghandami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray J, Saito S, Nakamura Y, and Niikawa N: A SNP in the ABCC11 gene is the determinant of human earwax type. Nat. Genet. 38: 324-330, 2006.
Kawashima M, Tamiya G, Oka A, Hohjoh H, Juji T, Ebisawa T, Honda Y, Inoko H, and Tokunaga K: Genome-wide association analysis of human narcolepsy and a new resistance gene. Am. J. Hum. Genet. 79: 252-263, 2006.
Fujimoto A, Kimura R, Ohashi J, Omi K, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Furusawa T, Nakazawa M, Ohtsuka R, and Tokunaga K: A scan for genetic determinants of human hair morphology: EDAR is associataed with Asian hair thickness. Hum. Mol. Genet. 17(6): 835-843, 2008.
Nakatsuji N, Nakjima F, and Tokunaga K: Highly efficient HLA-haplotype banking of pluripotent stem cell lines is possible by identification of homozygotes and production of induced pluriptetent stem cells. Nat. Biotech. 26(7): 739-740, 2008.
Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MCY, Ma RCW, So WY, Chan JCN, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, and Kasuga M: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat. Genet. 40(9): 1092-1097, 2008.
Miyagawa T, Kawashima M, Nishida N, Ohashi J, Kimura R, Fujimoto A, Shimada M, Morishita S, Shigeta T, Lin L, Hong SC, Faraco J, Shin YK, Jeong JH, Okazaki Y, Tsuji S, Honda M, Honda Y, Mignot E, and Tokunaga K: Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat. Genet. 40(11): 1324-1328, 2008.
Hallmayer J, Faraco J, Ling L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong S, Honda Y, Honda M, Hogl B, Longstreth WT, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erthardt C, Hesla PE, Poli F, Frauscher B, Jeong J-H, Lee S-P, Ton TGN, Kvale M, Kolesar L, Dobrovolna M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok P-Y, Risch N, and Mignot E: Narcolepsy is strongly associated with the TCR alpha locus. Nat. Genet. 41(6): 708-711, 2009.
Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, and Mizokami M: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat. Genet. 41: 1105-1109, 2009.
HUGO Pan-Asian SNP Consortium. Mapping human genetic diversity in Asia. Science 326: 1541-1545, 2009.
Okamato K, Iwasaki N, Nishimura C, Doi K, Noiri E, Nakamura S, Takizawa M, Ogata M, Fujimaki R, Grarup N, Pisinger C, Borch-Johnsen K, Lauritzen T, Sandbaek A, Hansen T, Yasuda K, Osawa H, Nanjo K, Kadowaki T, Kasuga M, Pedersen O, Fujita T, Kamatani N, Iwamoto Y, and Tokunaga K: Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Am. J. Hum. Genet. 86: 54-64, 2010.
Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, and Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat. Med. 16: 678-686, 2010.
Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Hogl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, and Mignot E: Common variants in P2RY11 are associated with narcolepsy. Nat. Genet. 43: 66-71, 2011.
Okamoto K, Tokunaga K, Doi, K, Fujita T, Suzuki H, Katoh T, Watanabe T, Nishida N, Mabuchi A, Takahashi A, Kubo M, Maeda S, Nakamura Y, and Noiri E: Common variation in GPC5 is associated with acquired nephrotic syndrome. Nat. Genet. 43: 459-463, 2011.
Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl E, Kurreman F, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthigton J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, and Yamamoto K: Meta-analysis of genome-wide association studies identifies multiple novel loci associated with rheumatoid arthritis in the Japanese population. Nat. Genet. 44(5): 511-517, 2012.
Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, and Ishibashi H: Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in Japanese. Am. J. Hum. Genet. 91(4): 721-728, 2012.
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieude P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapaa-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; RACI consortium; GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM: Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506(7488): 376-381, 2014.
Miyadera H, Ohashi J, Lernmark A, Kitamura T, and Tokunaga K: Cell surface MHC density profiling reveals instability of autoimmunity-associated HLA. J. Clin. Invest. 125(1): 275-291, 2015.
Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M, Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, and Nakamura M. Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cirrhosis in the Japanese population. Hum. Mol. Genet. 26(3): 650-659, 2017.
Nishida N, Sugiyama M, Sawai H, Nishina S, Sakai A, Ohashi J, Khor S-S, Kakisaka K, Tsuchiura T, Hino K, Sumazaki R, Takikawa Y, Murata K, Kanda T, Yokosuka O, Tokunaga K, and Mizokami M. Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine. Hepatology 2018 Mar (Epub ahead of print)
Jia X, Horinouchi T, Hitomi Y, Shono A, Khor SS, Omae Y, Kojima K, Kawai Y, Nagasaki M, Kaku Y, Okamoto T, Ohwada Y, Ohta K, Okuda Y, Fujimaru R, Hatae K, Kumagai N, Sawanobori E, Nakazato H, Ohtsuka Y, Nakanishi K, Shima Y, Tanaka R, Ashida A, Kamei K, Ishikura K, Nozu K, Tokunaga K, and Iijima K. for the Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan. Strong association of HLA-DR/DQ locus with childhood steroid-sensitive nephrotic syndrome in the Japanese population. J. Am. Soc. Nephrol. 29(8): 2189-2199, 2018.
Omae Y, Ito S, Takeuchi M, Isa K, Ogasawara K, Kawabata K, Oda A, Kaito S, Tsuneyama H, Uchikawa M, Wada I, Ohto H, and Tokunaga K. Integrative genome analysis identified the KANNO blood group antigen as prion protein. Transfusion 59(7): 2429-2435, 2019.